<b> Eligibility criteria </b> |
< 80 years old, no cognitive impairment, no history of stroke, dementia diagnosis and other related diseases. |
Same + MMSE above 26 at baseline |
<b> Treatment strategies </b> |
0. Natural course (comparison arm) <br>
1. Keep SBP < 120 mmHg <br>
2. Keep SBP < 140 mmHg <br>
3. Reduce SBP by 20% if >140 mmHg <br>
4. Quit smoking <br>
5. Joint 3 + 4 |
Same |
<b> Follow-up </b> |
From year of first visit until 15 years of follow-up, or year of stroke/dementia or death, which ever happened first |
Same + visit process simulation |
<b> Outcome </b> |
Stroke and Dementia (Death as a competing event) |
Same |
<b> Causal contrast </b> |
What would have been observed if all individuals adhered to their assigned strategy over 15 years (Per protocol effect) |
Same |